protein

IMPA3 Protein, Mouse (HEK293, His)

HY-P70865

10 μg;50 μg

107;300 USD

IMPA3 Protein, Mouse (HEK293, His)

proteins

HEK293

10 μg;50 μg

107;300 USD

IMPA3 protein has 3'-nucleotidase activity and can hydrolyze PAP into AMP and phosphate. This function suggests a role in the formation of bone components during endochondral ossification by scavenging PAP produced by Golgi sulfotransferases. IMPA3 Protein, Mouse (HEK293, His) is the recombinant mouse-derived IMPA3 protein, expressed by HEK293 , with N-6*His labeled tag. The total length of IMPA3 Protein, Mouse (HEK293, His) is 306 a.a., with molecular weight of ~38.0 kDa.

Mouse

IMPA3 protein demonstrates 3'-nucleotidase activity, specifically hydrolyzing adenosine 3',5'-bisphosphate (PAP) into adenosine 5'-monophosphate (AMP) and a phosphate. This enzymatic function suggests a potential role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation. Notably, IMPA3 exhibits no activity toward 3'-phosphoadenosine 5'-phosphosulfate (PAPS) or inositol phosphate (IP) substrates, including I(1)P, I(1,4)P2, I(1,3,4)P3, I(1,4,5)P3, and I(1,3,4,5)P4. The selective enzymatic profile of IMPA3 underscores its specific involvement in nucleotide metabolism and its potential regulatory role in skeletal development processes.

Inositol monophosphatase 3; Impad1

Greater than 95% as determined by reducing SDS-PAGE.

Supplied as a 0.2 μm filtered solution of 50 mM Tris-HCl, 150 mM NaCl, 10% Glycerol, pH 7.5.

Shipping with dry ice.