protein

Noggin Protein, Mouse (CHO)

HY-P7086

2 μg;10 μg;20 μg;50 μg;100 μg

40;100;160;300;510 USD

Noggin Protein, Mouse (CHO)

proteins

CHO

2 μg;10 μg;20 μg;50 μg;100 μg

40;100;160;300;510 USD

375588549

Noggin Protein, Mouse (CHO) is a bone morphogenetic protein (BMP) antagonist.

Mouse

Mammalian noggin is remarkably similar in its sequence to Xenopus noggin, and is similarly active in induction assays performed on Xenopus embryo tissues. In the adult mammal, noggin is most notably expressed in the nervous system [1] . Noggin is a bone morphogenetic protein (BMP) antagonist expressed in Spemann's organizer. Murine Noggin is expressed in condensing cartilage and immature chondrocytes. In mice lacking Noggin, cartilage condensations initiated normally but developed hyperplasia, and initiation of joint development failed [2] . Noggin protein binds BMP4with high affinity and can abolish BMP4 activity by blocking binding to cognate cell-surface receptors [3] . Human Noggin (hNoggin) has 205 amino acids (residues 28–232) after removal of its signal sequence (residues 1–27) and is secreted as a glycosylated, covalently linked homodimer. Human Noggin binds with high affinity to hBMP-4 (and with lower affinity to hBMP-7 [4] .

rMuNoggin; NOG

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized after extensive dialysis against PBS or 20 mM PB, 500 mM NaCl , pH 7.4, 5% trehalose, mannitol and 0.01% Tween 80 or PBS, pH 7.4, 8% trehalose.

Room temperature in continental US; may vary elsewhere.