protein

HABP2 Protein, Human (HEK293, His)

HY-P70832

5 μg;10 μg;50 μg;100 μg

75;130;400;670 USD

HABP2 Protein, Human (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

75;130;400;670 USD

HABP2 is a protein that cleaves the alpha chain of fibrinogen as well as the beta chain between "Lys-53" and "Lys-54" at multiple sites, preventing direct formation of a fibrin clot. It activates coagulation factor VII and converts prourokinase into its active form. HABP2 Protein, Human (HEK293, His) is the recombinant human-derived HABP2 protein, expressed by HEK293 , with C-6*His labeled tag.

Human

HABP2, a multifunctional protein, exhibits proteolytic activity by cleaving the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' of fibrinogen, while sparing the gamma-chain, thereby preventing direct initiation of fibrin clot formation and fibrinolysis. Notably, HABP2 does not activate prothrombin and plasminogen but facilitates the conversion of pro-urokinase to its active two-chain form. Additionally, it serves as an activator of coagulation factor VII. Beyond its role in hemostasis, HABP2 may act as a tumor suppressor, exerting negative regulation on cell proliferation and migration. Structurally, HABP2 exists as a heterodimer, with a 50 kDa heavy chain and a 27 kDa light chain linked by a disulfide bond.

Hyaluronan-binding protein 2; Factor VII-activating protease; Factor seven-activating protease; Hepatocyte growth factor activator-like protein; Plasma hyaluronan-binding protein

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 or 20 mM PB, 150 mM NaCl, pH 7.4.

Room temperature in continental US;may vary elsewhere.