protein

Semaphorin-3A/SEMA3A Protein, Human (HEK293, His-Flag)

HY-P70797

10 μg;50 μg;100 μg

100;280;450 USD

Semaphorin-3A/SEMA3A Protein, Human (HEK293, His-Flag)

proteins

HEK293

10 μg;50 μg;100 μg

100;280;450 USD

Semaphorin-3A/SEMA3A proteins are critical for shaping the olfactory system and influence puberty-related neuronal control. SEMA3A is known for inducing neuronal growth cone collapse, which leads to the formation of complex neuronal circuits by guiding the growth cone through a motor inhibitory mechanism. Semaphorin-3A/SEMA3A Protein, Human (HEK293, His-Flag) is the recombinant human-derived Semaphorin-3A/SEMA3A protein, expressed by HEK293 , with N-6*His, N-Flag labeled tag. The total length of Semaphorin-3A/SEMA3A Protein, Human (HEK293, His-Flag) is 521 a.a., with molecular weight of 70-75 kDa.

Human

The Semaphorin-3A/SEMA3A Protein plays a crucial role in the development of the olfactory system and exerts influence over neuronal control of puberty. Known for its capacity to induce the collapse and paralysis of neuronal growth cones, SEMA3A is implicated in guiding specific growth cones through a motility-inhibiting mechanism, thereby contributing to the intricacies of neuronal circuit formation. This protein serves as a ligand by binding to the complex neuropilin-1/plexin-1, underscoring its involvement in transducing signaling cues critical for neuronal guidance. Additionally, SEMA3A interacts with PLXND1, further highlighting its multifaceted role in mediating cellular interactions during the intricate processes of olfactory system development and the regulation of puberty-related neuronal functions.

Synonyms: Semaphorin III; SEMA3A; SEMAD; Hsema-I; SEMA1; SemD; Semad; coll-1 ; Hsema-III; Sema III

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, 5% Trehalose, pH 7.4 or 20mM Tris-HCl, 10% Trehalose, 100mM NaCl, 0.05% Tween 80, pH 8.5 or PBS, pH 7.4, 8% trehalose.

Room temperature in continental US; may vary elsewhere.