protein

IL-22 Protein, Mouse

HY-P7079

2 μg;10 μg;50 μg;100 μg;500 μg

45;125;400;550;1450 USD

IL-22 Protein, Mouse

proteins

E. coli

2 μg;10 μg;50 μg;100 μg;500 μg

45;125;400;550;1450 USD

375588540

IL-22 Protein, Mouse plays a prominent role in epithelial regeneration and dampening of chronic inflammatory responses by protecting intestinal stem cells from immune-mediated tissue damage.

Mouse

Interleukin-22 (IL-22) is a member of the IL-10 family of cytokines, expressed predominantly by subsets of innate lymphoid cells (ILCs) and activated T cells, including T helper 1 (TH1) cells, TH17 cells and TH22 cells. IL-22 can be recognized by a heterodimeric receptor complex that consists of two transmembrane subunits: IL-22R1 and IL-10R2. The binding of IL-22 to its receptor activates the JAK/STAT and MAPK signaling pathway, resulting in gene expression or repression. Since the IL-10R2 is shared by five cytokines (IL-10, IL-22, IL-26, IL-28, and IL-29) and is widely expressed in most cells, the expression of the IL-22R1 determines whether a cell is the target of IL-22. IL-22 has a considerable therapeutic potential in graft-versus-host disease (GVHD), which is a frequent and challenging complication following allogeneic stem cell transplantation [1] .

rMuIL-22; Cytokine Zcyto 18; IL-TIF

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.22 μm filtered solution of PBS or 20 mM PB, 150 mM NaCl, pH 7.0-7.4 or 50 mM Tris-HCL, 300 mM NaCl, 10 mM Imidazole, pH 8.0.

Room temperature in continental US; may vary elsewhere.