protein

ACE2 Protein, Human (Biotinylated, HEK293, His-Avi)

HY-P70769

20 μg

290 USD

ACE2 Protein, Human (Biotinylated, HEK293, His-Avi)

proteins

HEK293

20 μg

290 USD

ACE2 Protein, Human (Biotinylated, HEK 293, His-Avi) is a metallopeptidase which binds effectively to the S1 domain of the SARS‐CoV protein. ACE2 Protein, Human is also an essential regulator of cardiac function and blood pressure control.

Human

Angiotensin‐converting enzyme 2 (ACE2), a metallopeptidase, is the functional receptor for SARS‐CoV. ACE2 can be immunoprecipitated by the S1 domain of the SARS‐CoV virus and that ACE2 can promote viral replication. ACE2 is abundantly present in humans in the epithelia of lung and small intestine, which might provide possible routes of entry for the SARS‐CoV. ACE2, previously identified as the cellular receptor for SARS-CoV, also acts as a receptor of the new coronavirus (SARS-CoV-2). ACE2 is also thought to be an essential regulator of cardiac function and blood pressure control, possibly by acting as a natural counterpart of ACE1 [1] [2] .

Angiotensin-Converting Enzyme 2; ACE-Related Carboxypeptidase; Angiotensin-Converting Enzyme Homolog; ACEH; Metalloprotease MPROT15; ACE2

Greater than 95% as determined by reducing SDS-PAGE.

Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 300 mM NaCl, 1 mM ZnCl 2 , 10% Glycerol, pH 7.4.

Shipping with dry ice