protein

IL-1RL2 Protein, Mouse (A158V, HEK293, His)

HY-P70748

10 μg;50 μg

100;280 USD

IL-1RL2 Protein, Mouse (A158V, HEK293, His)

proteins

HEK293

10 μg;50 μg

100;280 USD

The IL-1RL2 protein functions as a receptor for interleukin 36 (IL36A, IL36B, and IL36G) and upon binding forms a complex with the coreceptor IL1RAP. This IL-36 receptor complex plays a key role in activating NF-κ-B, MAPK, and other signaling pathways. IL-1RL2 Protein, Mouse (A158V, HEK293, His) is the recombinant mouse-derived IL-1RL2 protein, expressed by HEK293 , with C-6*His labeled tag.

Mouse

IL-1RL2 Protein serves as the receptor for interleukin-36 (IL36A, IL36B, and IL36G). Upon binding to interleukin-36, it forms a complex with the coreceptor IL1RAP, constituting the interleukin-36 receptor complex. This complex plays a pivotal role in mediating interleukin-36-dependent activation of NF-kappa-B, MAPK, and other signaling pathways. The IL-36 signaling system is believed to be present in epithelial barriers, participating in local inflammatory responses and sharing similarities with the IL-1 system. IL-1RL2 appears to be involved in the skin's inflammatory response, potentially inducing the IL-23/IL-17/IL-22 pathway. These interactions highlight the significance of IL-1RL2 in the regulation of immune responses, particularly in the context of epithelial barriers and local inflammation.

Interleukin-1 receptor-like 2; IL1RL2; IL-36 receptor; IL-36R; IL-1Rrp2; IL1R-rp2

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US;may vary elsewhere.