protein

Siglec-9 Protein, Human (HEK293, His)

HY-P70739

10 μg;50 μg

160;450 USD

Siglec-9 Protein, Human (HEK293, His)

proteins

HEK293

10 μg;50 μg

160;450 USD

Siglec-9 Protein is a member of the Siglec cell surface immunoglobulin family.Siglec-9 is highly expressed on human neutrophils and monocytes and low on natural killer cells, and sub-populations of T and B lymphocytes.Siglec-9 induces human neutrophil apoptosis and autophagy-like cell death and also inhibits tumor activity.Siglec-9 Protein, Human (HEK293, His) is the recombinant human-derived Siglec-9 protein, expressed by HEK293 , with C-6*His labeled tag.

Human

Sialic acid-binding immunoglobulin-like lectin (Siglec-9) is a member of the Siglec cell surface immunoglobulin family. Siglec-9 is highly expressed on human neutrophils and monocytes and low on natural killer cells, and sub-populations of T and B lymphocytes. Ligation of Siglec-9 by chemical compounds or synthetic ligands induced apoptosis and autophagic-like cell death in human neutrophils. Siglec-9 binds to sialic acid and transduces apoptotic and nonapoptotic death signals to neutrophils. Siglec-9 is an immune-checkpoint molecule on macrophages that can be targeted to enhance anti-PD-1/PD-L1 therapeutic efficacy for GBM treatment. Pro-tumorigenic activity can be suppressed by blocking Siglec-9, which unleashes antitumor functions and induces robust tumor-eliminating activity. Targeting Siglec-9 could be beneficial for the treatment of COPD, asthma, fibrosis, and related chronic inflammatory lung diseases [1] [2] [3] .

Sialic acid-binding Ig-like lectin 9; Siglec-9; CDw329; Protein FOAP-9; SIGLEC9

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, 2 mM EDTA, pH 7.4.

Room temperature in continental US;may vary elsewhere.