protein

CD38 Protein, Human (HEK293, His, solution)

HY-P70731

10 μg;50 μg

170;476 USD

CD38 Protein, Human (HEK293, His, solution)

proteins

HEK293

10 μg;50 μg

170;476 USD

The CD38 protein plays a key role in cell signaling, proficiently synthesizing cyclic ADP-ribose (cADPR) as a critical second messenger for glucose-induced insulin secretion. It also promotes the synthesis of the calcium mobilizer niacin-adenine dinucleotide phosphate (NAADP+). CD38 Protein, Human (HEK293, His, solution) is the recombinant human-derived CD38 protein, expressed by HEK293 , with C-6*His labeled tag.

Human

The CD38 Protein assumes a pivotal role in cellular signaling, being a proficient synthesizer of cyclic ADP-ribose (cADPR), a recognized second messenger crucial for glucose-induced insulin secretion. Moreover, it facilitates the synthesis of the calcium mobilizer nicotinate-adenine dinucleotide phosphate, NAADP(+), derived from 2'-phospho-cADPR and nicotinic acid, as well as from NADP(+) and nicotinic acid. Operating at both pH 5.0 and pH 7.4, CD38 Protein exhibits a preference for transforming 2'-phospho-cADPR into NAADP(+) while selectively cleaving NADP(+) to cADPR and ADPRP rather than generating NADDP(+). Notably, it also showcases cADPR hydrolase activity, highlighting its multifaceted role in the dynamic regulation of these crucial signaling molecules. The integration of these activities underscores the significance of CD38 Protein in modulating cellular responses, particularly in the context of insulin secretion and calcium mobilization.

ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; ADP-ribosyl cyclase 1; Cyclic ADP-ribose hydrolase 1; CD38 antigen; CD38 molecule; CD38

Greater than 95% as determined by reducing SDS-PAGE.

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

Shipping with dry ice