protein

Thrombomodulin Protein, Human (HEK293, His)

HY-P70724A

5 μg;10 μg;50 μg;100 μg

74;125;350;595 USD

Thrombomodulin Protein, Human (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

74;125;350;595 USD

Thrombomodulin, an endothelial cell receptor, forms a 1:1 complex with thrombin, vital for coagulation regulation. This complex activates protein C, converting it to protein Ca. Protein Ca then inhibits the activated cofactors (factor Va and factor VIIIa) of the coagulation cascade, suppressing thrombin generation. Thrombomodulin's interaction with ITGAL, ITGAM, and ITGB2 emphasizes its role in immune response modulation. Thrombomodulin Protein, Human (HEK293, His) is the recombinant human-derived Thrombomodulin protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Thrombomodulin Protein, Human (HEK293, His) is 497 a.a., with molecular weight of ~64-67 kDa.

Human

Thrombomodulin, a distinctive endothelial cell receptor, establishes a precise 1:1 stoichiometric complex with thrombin, playing a crucial role in the regulation of coagulation. This complex facilitates the conversion of protein C to its activated form, protein Ca. Once activated, protein Ca acts by cleaving the activated cofactors of the coagulation cascade, namely factor Va and factor VIIIa, effectively curbing the generation of thrombin. Thrombomodulin's interaction with ITGAL, ITGAM, and ITGB2 further underscores its involvement in modulating immune responses.

Thrombomodulin; THBD; TM; Fetomodulin; CD141; THRM

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl, pH 8.0

Room temperature in continental US; may vary elsewhere.