protein

SIRP beta 1 Protein, Human (HEK293, His)

HY-P70719

10 μg;50 μg;100 μg;500 μg;1 mg

89;250;425;1100;1760 USD

SIRP beta 1 Protein, Human (HEK293, His)

proteins

HEK293

10 μg;50 μg;100 μg;500 μg;1 mg

89;250;425;1100;1760 USD

SIRP beta 1 protein negatively regulates receptor tyrosine kinase signaling and recruits SYK for myeloid cell activation. It interacts with TYROBP as a homodimer, facilitating SYK recruitment. This intricate molecular interplay is crucial for modulating myeloid cell activation and regulating cellular signaling. SIRP beta 1 occupies a central position in protein interactions that contribute to its functional role. SIRP beta 1 Protein, Human (HEK293, His) is the recombinant human-derived SIRP beta 1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of SIRP beta 1 Protein, Human (HEK293, His) is 333 a.a., with molecular weight of 45-55 kDa.

Human

SIRP beta 1 protein, an immunoglobulin-like cell surface receptor, plays a vital role in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Additionally, it participates in the recruitment of the tyrosine kinase SYK, triggering the activation of myeloid cells when associated with TYROBP. Existing as a homodimer with disulfide linkages, SIRP beta 1 interacts specifically with TYROBP, leading to the recruitment of SYK. This intricate molecular interplay positions SIRP beta 1 at the nexus of cellular signaling regulation, highlighting its significance in modulating myeloid cell activation and the intricate network of protein interactions that contribute to its functional role.

Signal-regulatory protein beta-1; SIRP-beta-1; CD172 antigen-like family member B; CD172b; SIRPB1

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 or 20 mM PB, 150 mM NaCl, pH 7.4.

Room temperature in continental US; may vary elsewhere.