product summary
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company name :
MedChem Express LLC
product type :
protein
product name :
TREM-1 Protein, Mouse (HEK293, His)
catalog :
HY-P70716
quantity :
10 μg;50 μg
price :
115;320 USD
more info or order :
product information
Catalog Number :
HY-P70716
Product Name :
TREM-1 Protein, Mouse (HEK293, His)
Product Type :
proteins
Host Species :
HEK293
Size :
10 μg;50 μg
List Price :
115;320 USD
Product Description :
The TREM-1 protein is a key cell surface receptor that amplifies inflammatory responses in innate and adaptive immunity. Ligands such as PGLYRP1, HMGB1 or HSP70 activate TREM-1, leading to multimerization and complex formation with TYROBP/DAP12. TREM-1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived TREM-1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TREM-1 Protein, Mouse (HEK293, His) is 182 a.a., with molecular weight of ~38.0 kDa.
SpeciesSummary :
Mouse
Background :
TREM-1, a cell surface receptor, assumes pivotal roles in both innate and adaptive immunity by robustly amplifying inflammatory responses. Upon activation by diverse ligands such as PGLYRP1, HMGB1, or HSP70, TREM-1 undergoes multimerization and forms a complex with the transmembrane adapter TYROBP/DAP12. This initiates a SYK-mediated cascade of tyrosine phosphorylation, activating downstream mediators like BTK, MAPK1, MAPK3, or phospholipase C-gamma. Consequently, this cascade facilitates the release of pro-inflammatory cytokines and/or chemokines by neutrophils and macrophages, promoting their migration and thereby amplifying inflammatory responses triggered by bacterial and fungal infections. Beyond microbial interactions, TREM-1 also contributes to the amplification of inflammatory signals initiated by Toll-like receptor (TLR) and NOD-like receptor engagement, playing a crucial role in the pathophysiology of various acute and chronic inflammatory diseases, including septic shock and atherosclerosis. In its monomeric state, TREM-1 forms homomultimers upon activation and interacts with TYROBP/DAP12 and TLR4, further highlighting its intricate involvement in the regulation of immune responses.
ALTnames :
Triggering receptor expressed on myeloid cells 1; TREM-1; CD354; Trem1
Purity :
Greater than 95% as determined by reducing SDS-PAGE.
Buffer :
Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Storage :
Room temperature in continental US;may vary elsewhere.
more info or order :
company information
MedChem Express LLC
18 Wilkinson Way, Princeton, NJ 08540
sales@medchemexpress.com
http://www.medchemexpress.com609-228-6898
headquarters: USA