protein

FCRN-B2M Protein, Mouse (HEK293, His)

HY-P70656

10 μg;50 μg

90;270 USD

FCRN-B2M Protein, Mouse (HEK293, His)

proteins

HEK293

10 μg;50 μg

90;270 USD

The FCRN protein is a cell surface receptor that conveys passive humoral immunity through the selective uptake of monomeric IgG in milk. FCRN-B2M Protein, Mouse (HEK293, His) is a recombinant protein dimer complex containing mouse-derived FCRN protein, expressed by HEK293 , with C-6*His labeled tag. FCRN-B2M Protein, Mouse (HEK293, His), has molecular weight of 42-58 & 12 kDa, respectively.

Mouse

FCRN, a vital cell surface receptor, facilitates the transfer of passive humoral immunity from the mother to the newborn. Recognizing the Fc region of monomeric immunoglobulin gamma, it selectively uptakes IgG from milk, particularly at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes undergo transcytosis across the intestinal epithelium, releasing IgG from FcRn into blood or tissue fluids. This process contributes significantly to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells facilitates the recycling of IgG to the cell surface, releasing it into circulation. Notably, besides its role in IgG homeostasis, the FcRn complex, consisting of two subunits, p51, and p14 (equivalent to beta-2-microglobulin), forms an MHC class I-like heterodimer, highlighting its pivotal role in immune and protein homeostasis. Furthermore, FCRN interacts with albumin/ALB, regulating the homeostasis of this other most abundant circulating protein.

IgG receptor FcRn; Neonatal Fc receptor; FCRN

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US;may vary elsewhere.