protein

IL-1RL2 Protein, Human (HEK293, Fc)

HY-P70625

10 μg;50 μg

95;260 USD

IL-1RL2 Protein, Human (HEK293, Fc)

proteins

HEK293

10 μg;50 μg

95;260 USD

IL-1RL2 Protein, serving as a receptor for interleukin-36 (IL36A, IL36B, and IL36G), forms a complex with the coreceptor IL1RAP, constituting the interleukin-36 receptor. This complex activates NF-kappa-B, MAPK, and other pathways, resembling the IL-1 system. IL-1RL2 is implicated in local inflammatory responses at epithelial barriers, particularly contributing to skin inflammatory reactions by inducing the IL-23/IL-17/IL-22 pathway. IL-1RL2 Protein, Human (HEK293, Fc) is the recombinant human-derived IL-1RL2 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of IL-1RL2 Protein, Human (HEK293, Fc) is 318 a.a., with molecular weight of 80-110 kDa.

Human

IL-1RL2, a receptor for interleukin-36 (IL36A, IL36B, and IL36G), engages in complex signaling events upon binding to interleukin-36. Through association with the coreceptor IL1RAP, the interleukin-36 receptor complex is formed, orchestrating interleukin-36-dependent activation of NF-kappa-B, MAPK, and other pathways. This signaling system, akin to the IL-1 system, is implicated in local inflammatory responses within epithelial barriers, particularly contributing to skin inflammatory reactions by inducing the IL-23/IL-17/IL-22 pathway.

Interleukin-1 receptor-like 2; IL1RL2; IL-36 receptor; IL-36R; IL-1Rrp2; IL1R-rp2;

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.