protein

PKM2 Protein, Human (530a.a, His)

HY-P70599

10 μg;50 μg

88;245 USD

PKM2 Protein, Human (530a.a, His)

proteins

E. coli

10 μg;50 μg

88;245 USD

PKM2 Protein, Human (530a.a, His) is a recombinant PKM2 protein with a His-Flag. PKM2 Protein is one of the rate-limiting enzymes in glycolysis [3] .

Human

PKM2 is specifically expressed in proliferating cells, such as embryonic stem cells, embryonic carcinoma cells, and various cancer cells. PKM2 functions as a glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. PKM2 is one of the rate-limiting enzymes in glycolysis, interacts with mitofusin 2 (MFN2), a key regulator of mitochondrial fusion, to promote mitochondrial fusion and OXPHOS, and attenuate glycolysis [1] [2] [3] .

Pyruvate kinase PKM; CTHBP; OIP-3; THBP1

Greater than 90% as determined by reducing SDS-PAGE.

Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 50 mM NaCl, 0.05% Brij-35, 1 mM DTT, pH 7.5.

Shipping with dry ice