protein

IRF5 Protein, Human

HY-P70573

10 μg;50 μg;100 μg

170;510;820 USD

IRF5 Protein, Human

proteins

E. coli

10 μg;50 μg;100 μg

170;510;820 USD

The IRF5 protein is a key transcription factor in innate immunity and activates type I interferon (IFN) and inflammatory cytokine genes through endolysosomal Toll-like receptors (TLR7, TLR8, TLR9). It regulates IFN genes and IFN-stimulated genes (ISGs) by binding to ISREs in their promoters. IRF5 Protein, Human is the recombinant human-derived IRF5 protein, expressed by E. coli , with C-6*His labeled tag.

Human

IRF5, a critical transcription factor, assumes a pivotal role in innate immunity by orchestrating the activation of type I interferon (IFN) genes, including IFNA and INFB, and inflammatory cytokines downstream of endolysosomal toll-like receptors (TLR7, TLR8, and TLR9). It functions as a key regulator in the transcription of type I IFN genes and IFN-stimulated genes (ISG) by binding to the interferon-stimulated response element (ISRE) in their promoters. Notably, IRF5 efficiently activates both IFN-beta (IFNB) and IFN-alpha (IFNA) genes, mediating their induction through the TLR-activated, MyD88-dependent pathway. Particularly relevant in the context of SARS-CoV-2 infection, IRF5 stands out as a significant transcriptional regulator of the IFN response. Maintained as a monomer in an autoinhibited state, its activation involves phosphorylation facilitated by the innate adapter protein TASL, which recruits IRF5, licensing it for phosphorylation by IKBKB. Subsequent steps involve the dissociation of phosphorylated IRF5 from adapter proteins, its dimerization, and nuclear entry to induce IFNs.

Interferon Regulatory Factor 5; IRF-5; IRF5

Greater than 95% as determined by reducing SDS-PAGE.

Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl, 30% Glycerol, 1 mM DTT, pH 8.0.

Shipping with dry ice