protein

TSLP Protein, Human

HY-P7057

10 μg;50 μg;100 μg

190;640;950 USD

TSLP Protein, Human

proteins

E. coli

10 μg;50 μg;100 μg

190;640;950 USD

375588520

TSLP Protein, Human is an epithelial cell-derived cytokine which plays key role in allergic inflammation.

Human

Thymic stromal lymphopoietin (TSLP) is an epithelial cell derived cytokine expressed in skin, gut, lungs and thymus. TSLP signals via TSLPR, a heterodimer of the IL-7 receptor alpha chain (IL-7Rα) and the TSLP receptor chain (TSLPR). Thymic stromal lymphopoietin exerts profound influence on the polarization of dendritic cells (DCs) to drive T helper (Th) 2 cytokine production. It also directly promotes T cell proliferation in response to T cell receptor (TCR) activation, and Th2 cytokine production. Thymic stromal lymphopoietin also supports B cell expansion and differentiation. Thymic stromal lymphopoietin further amplifies Th2 cytokine production by mast cells and NKT cells [1] . Multiple innate immune cells express the TSLPR and respond to TSLP. For example, Thymic stromal lymphopoietin can enhance cytokine production from mast cells, NKT cells and eosinophils. In addition, Thymic stromal lymphopoietin has very recently been shown to induce eosinophil extracellular traps (EETs), extrusions of mitochondrial DNA toxic granule molecules released in response to infection [2] .

rHuTSLP; TSLP

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized after extensive dialysis against 20 mM PB, pH 7.4, 150 mM NaCl or PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.