protein

GMP Noggin Protein, Human (HEK293)

HY-P70558G

50 μg

700 USD

GMP Noggin Protein, Human (HEK293)

proteins

HEK293

50 μg

700 USD

Noggin protein is an important BMP inhibitor that plays an indispensable role in the neural tube, somite growth, cartilage morphogenesis, and joint formation. Its homodimeric structure promotes significant interactions with GDF5 and possibly GDF6, inhibiting chondrocyte differentiation. GMP Noggin Protein, Human (HEK293) is the recombinant human-derived Noggin protein, expressed by HEK293 , with C-6*His labeled tag. The total length of GMP Noggin Protein, Human (HEK293) is 205 a.a., with molecular weight of ~28-32 kDa.

Human

Noggin protein emerges as a crucial inhibitor in the intricate realm of bone morphogenetic proteins (BMP) signaling, playing indispensable roles in neural tube and somite growth, as well as contributing to the intricate processes of cartilage morphogenesis and joint formation. Operating through its homodimeric structure, Noggin establishes a significant interaction with GDF5, and likely GDF6, exerting its inhibitory influence on chondrocyte differentiation. This molecular interplay underscores Noggin's pivotal position in regulating key aspects of embryonic development, emphasizing its nuanced involvement in sculpting the intricate patterns and structures critical for proper growth and morphogenesis.

Noggin; NOG

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized a 0.22 μm filtered solution of 20mM PB, 500mM NaCl, 2mM EDTA, pH 7.4.

Room temperature in continental US; may vary elsewhere.