protein

IL-2R gamma/CD132 Protein, Human (HEK293, His)

HY-P70556

10 μg;50 μg

100;280 USD

IL-2R gamma/CD132 Protein, Human (HEK293, His)

proteins

HEK293

10 μg;50 μg

100;280 USD

IL-2R gamma (CD132), a type I cytokine receptor expressed on leucocyte subsets, is a receptor for IL-2. IL-2R gamma forms heterodimer with IL-2R beta, and increases the affinity of IL-2R beta for IL-2 [1] . IL-2R gamma plays an important role in the development, activation, proliferation, differentiation and regulation of lymphocytes and other cell types [2] . IL-2R gamma/CD132 Protein, Human (HEK293, His) is a recombinant human extracellular region of IL-2R gamma (L23-A262) with a C-Terminal 6*His tag, which is produced in HEK293 cells.

Human

IL-2R gamma (CD132), a receptor for IL-2, is a member of the type I cytokine receptor family and type 5 subfamily. IL-2R gamma is expressed in leucocyte subsets and human monocytes [1] [3] . Human IL-2R gamma consists of extracellular domain (L23-A262), helical domain (V263-L283), and cytoplasmic domain (E284-T369). The sequence of amino acids in IL-2R beta differs in different species. Human IL-2R gamma shares IL-2R gamma has low-affinity for IL-2, but has intermediate affinity for IL-2 when forming heterodimer with IL-2R beta. IL-2R beta/gama heterodimer complex transduces a signal when IL-2 concentrations are relatively high [1] . IL-2R gamma can be utilized by the IL-2, IL-4, IL-7, IL-9, and IL-15 receptor, and takes part in the development, activation, proliferation, differentiation and regulation of lymphocytes and other cell types [2] . IL-2R gamma is tightly up-regulated by IL-2 and IFN gamma [3] . Mutations of L-2R gamm cause human X-linked severe combined immunodeficiency (XSCID) [4] . IL-2R gamma is involved in inflammatory response, and mediates activation of the cells [1] .

IL-2RG; IL-2 R gamma; IL-2Rγ; IL2R γ; Cytokine receptor common subunit gamma; Interleukin-2 receptor subunit gamma; gammaC; P64; CD132 and IL2RG

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

Room temperature in continental US;may vary elsewhere.