protein

VEGFR-2 Protein, Human (HEK293, His)

HY-P70552

2 μg;10 μg;50 μg;100 μg;500 μg

35;65;170;275;770 USD

VEGFR-2 Protein, Human (HEK293, His)

proteins

HEK293

2 μg;10 μg;50 μg;100 μg;500 μg

35;65;170;275;770 USD

VEGFR-2 is a tyrosine-protein kinase of the cell surface receptors of VEGFA, VEGFC, and VEGFD that mediates activation of the MAPK1/ERK2 , MAPK3/ERK1 , and MAP kinase signaling pathways, as well as the AKT1 signaling pathway. VEGFR-2 can promote the proliferation, survival, migration and differentiation of endothelial cells. Overexpression of VEGFR-2 is associated with the development of tumors. VEGFR-2 Protein, Human (HEK293, His) is the recombinant human-derived VEGFR-2 protein, expressed by HEK293 , with C-His labeled tag. The total length of VEGFR-2 Protein, Human (HEK293, His) is 745 a.a., with molecular weight of 84-140 kDa.

Human

VEGF receptors (VEGFRs) are receptors for vascular endothelial growth factor (VEGF), and there are three main subtypes, VEGFR-1, VEGFR-2, and VEGFR-3. VEGFR-2 acts as a tyrosine-protein kinase of the cell surface receptor for VEGFA, VEGFC and VEGFD, and plays an important role in angiogenesis, vascular development, vascular permeability and embryonic hematopoiesis. It can promote the proliferation, survival, migration and differentiation of endothelial cells. Promote actin cytoskeleton recombination. VEGFR-2 regulates VEGFR-1 (FLT1) and VEGFR-3 (FLT40) signaling by forming heterodimers. VEGFR-2 mediates the activation of , MAPK1/ERK2 , MAPK3/ERK1 and MAP kinase signaling pathways, as well as the AKT1 signaling pathway. It mediates phosphorylation of the phosphatidylinositol 3-kinase regulatory subunit PIK3R1 , recombination of actin cytoskeleton and activation of PTK2/FAK1 . Vegfa-mediated induction of NOS2 and NOS3 is required, resulting in endothelial cell production of the signaling molecule nitric oxide (NO). Phosphorylated PLCG1. Promotes phosphorylation of FYN, NCK1, NOS3, PIK3R1, PTK2/FAK1, and SRC. Overexpression of VEGFR-2 is associated with tumorigenesis [1] [2] [3] [4] [5] [6] .

Vascular endothelial growth factor receptor 2; KDR; VEGFR-2; Fetal liver kinase 1; FLK-1; Kinase insert domain receptor; Protein-tyrosine kinase receptor flk-1; VEGFR2; VEGF R2

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 or 20 mM PB, 150 mM NaCl, pH 7.4.

Room temperature in continental US; may vary elsewhere.