protein

CD4 Protein, Human (365a.a, HEK293, His)

HY-P70537

5 μg;10 μg;50 μg;100 μg;500 μg

40;70;170;290;750 USD

CD4 Protein, Human (365a.a, HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg;500 μg

40;70;170;290;750 USD

CD4 Protein is an integrated membrane glycoprotein that plays various roles in immune responses and defending against internal and external attacks. The alpha-helix structure of CD4 Protein and HIV-1 Vpu can be involved in the binding and degradation of CD4 molecules. CD4 Protein participates in the differentiation/activation, cytokine expression, and cell migration in macrophages or NK cells through a TCR/LCK-independent pathway. CD4 Protein can enhance the host's immune response to viral infections and boost anti-tumor immunity. CD4 Protein, Human (365 a.a, HEK293, His) is a recombinant CD4 protein with a His tag, expressed in HEK293. CD4 Protein, Human (365 a.a, HEK293, His) consists of 365 amino acids, with a molecular weight ranging from 49-58 kDa [1] [2] [3] .

Human

CD4 Protein is expressed on T helper cells and cytotoxic lymphocytes, interacting with class II major histocompatibility complex (MHC) antigens to mediate cell adhesion [4] . The expression of CD4 Protein in NK cells can promote the production of cytokines TNF-α and γ-IFN. These cytokines act as important mediators that enhance the host's immune response to viral infections and boost anti-tumor immunity. Additionally, CD4 Protein can mediate the migration of NK cells towards the chemokine IL-16, allowing NK cells to move to the site of acute inflammation, thereby enhancing their innate immune response capability [2] . CD4 protein can trigger the activation of Src family kinases, ERK1/2, and MAPK-dependent pathways, leading to the differentiation of monocytes into macrophages and resulting in increased expression of TLR8, thereby regulating the innate immune response; it can also induce calcium flux and signal transduction by participating in the ERK/MAPK/NF-κB pathway [3] . CD4 Protein can be downregulated and degraded by Vpu, and this proteolytic activity requires the phosphorylation of the phosphate receptor sites Ser52 and Ser56, as well as the presence of a second helical structure in the distal cytoplasmic region of Vpu [1] . CD4 protein is closely related to diseases like tumors and viral infections [2] .

T-cell surface glycoprotein CD4; T-cell surface antigen T4/Leu-3; sCD4

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 or 20 mM PB, 150 mM NaCl, pH 7.4.

Room temperature in continental US;may vary elsewhere.