protein

OSM Protein, Human (227a.a)

HY-P7052

2 μg;10 μg;50 μg;100 μg

70;190;620;930 USD

OSM Protein, Human (227a.a)

proteins

E. coli

2 μg;10 μg;50 μg;100 μg

70;190;620;930 USD

375588513

OSM Protein, Human (227a.a) is a polypeptide chain containing 227 amino acids. Oncostatin M is a cytokine belonging to the IL-6 family that has multiple functions in hematopoiesis, mesenchymal stem cell differentiation, liver regeneration, heart remodeling, nociception, inflammation and metabolism.

Human

Oncostatin M is a cytokine belonging to the IL-6 family that has multiple functions in hematopoiesis, mesenchymal stem cell differentiation, liver regeneration, heart remodeling, nociception, inflammation and metabolism. The full-length Oncostatin M proteins contain between 239 and 263 amino acids which fold into a long-chain four helix-bundle protein with an up-up-down-down topology representative of all other IL-6 family cytokines. Human Oncostatin-M can bind to either the type I receptor complex consisting of gp130 and the LIFR (gp130/LIFRb) or the type II receptor complex consisting of gp130 and the OSMR (gp130/OSMRb). In the murine system Oncostatin-M has been shown to bind with high affinity only to the type II gp130/OSMRb complex [1] [2] . Oncostatin-M binds to specific receptor complexes, then activates two major signaling pathways: Janus Kinase-Signal Transducers and Activators of Transcription (JAK-STAT) and Mitogen-Activated Protein Kinase (MAPK), to regulate downstream events [3] .

rHuOSM; OSM

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized after extensive dialysis against PBS or PBS, pH 7.4, 8% trehalose.

Room temperature in continental US; may vary elsewhere.