protein

CD44 Protein, Human (HEK293, His)

HY-P70507

5 μg;10 μg;50 μg;100 μg

40;70;170;240 USD

CD44 Protein, Human (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg

40;70;170;240 USD

CD44 Protein is a type of cell surface receptor protein. CD44 Protein mediates various signaling pathways, including protein kinases, changes in the cytoskeleton, intracellular pathways, proteases, and transcription factors, which promote cancer cell division, proliferation, invasion, angiogenesis, and metabolic changes. The expression level of CD44 Protein is positively correlated with the malignancy and invasiveness of glioblastoma. CD44 Protein, Human (HEK293, His) is a recombinant CD44 protein tagged with a C-6*His label, expressed by HEK293. CD44 Protein, Human (HEK293, His) consists of 200 amino acids and has a molecular weight of 38-50 kDa [1] [2] .

Human

CD44 Protein is a non-kinase transmembrane proteoglycan encoded by a gene located on human chromosome 11. The CD44 Protein has an extracellular domain, a membrane proximal region, a transmembrane domain, and a cytoplasmic tail [2] . CD44 Protein can bind with various ligands, including hyaluronic acid (HA), osteopontin (OPN), chondroitin, collagen, fibronectin, and serum glycosaminoglycan/sulfated proteoglycans [2] . CD44 Protein has various subtypes that undergo subtype switching in tumor cells, playing biological roles in the growth, metastasis, and prognosis of multiple tumors [2] . CD44 Protein plays a role in cell-to-cell interactions, cell adhesion, and migration, helping them sense and respond to changes in the tissue microenvironment [3] . The interaction of CD44 Protein-HA (hyaluronic acid) with Rac1-dependent PKNγ kinase activation can promote the phosphorylation of PLCγ1 and cortactin, leading to PLCγ1-mediated IP3 production/Ca 2+ signaling and cortactin-mediated cytoskeletal functions, which are essential for keratinocyte functions such as cell adhesion and differentiation [3] . CD44 Protein is closely related to pathological processes such as tumors, viral infections, pathological angiogenesis, and rheumatoid arthritis [2] .

CD44 Antigen; CDw44; Epican; Extracellular Matrix Receptor III; ECMR-III; GP90 Lymphocyte Homing/Adhesion Receptor; HUTCH-I; Heparan Sulfate Proteoglycan; Hermes Antigen; Hyaluronate Receptor; Phagocytic Glycoprotein 1; PGP-1; Phagocytic Glycoprotein I; PGP-I; CD44; LHR

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

Room temperature in continental US;may vary elsewhere.