protein

LIF Protein, Human

HY-P7049

2 μg;10 μg;50 μg;100 μg

35;82;250;420 USD

LIF Protein, Human

proteins

E. coli

2 μg;10 μg;50 μg;100 μg

35;82;250;420 USD

375588509

LIF Protein, Human is a lymphoid factor involved in various neural and inflammatory processes such as the acute-phase reaction, tissue damage, and infection.

Human

Leukemia Inhibitory Factor has been shown to possess a remarkable variety of actions. It releases calcium from bone tissue, and is the differentiation inhibitory factor preventing spontaneous differentiation in normal embryonic stem cells [1] . Leukemia inhibitory factor (LIF) is a neuropoietic cytokine involved in both the neural and immune responses to injury. Its levels are increased in a variety of animal and human inflammatory conditions. Administration of Leukemia Inhibitory Factor can suppress inflammatory signs in some cases, for instance after intratracheal lipopolysaccharide-induced inflammation. Leukemia Inhibitory Factor also increases corticosterone levels via the hypothalamo-pituitary-adrenal axis. Other evidence suggests, that it can also act as a proinflammatory cytokine. Exogenously added Leukemia Inhibitory Factor induces acute phase protein expression and stimulates the production of proinflammatory cytokines and monocyte chemoattractants [2] .

rHuLIF; Differentiation-stimulating Factor; D factor; MLPLI

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized after extensive dialysis against PBS.

Room temperature in continental US; may vary elsewhere.