protein

TIM-3/HAVCR2 Protein, Human (HEK293, His)

HY-P70482

10 μg;50 μg

100;280 USD

TIM-3/HAVCR2 Protein, Human (HEK293, His)

proteins

HEK293

10 μg;50 μg

100;280 USD

T cell immunoglobulin mucin-3 is an inhibitory receptor, and inhibits T cell functions. TIM-3 regulates immune responses in autoimmunity and cancer. TIM-3 has multiple different ligands: galectin 9, phosphatidylserine (PtdSer), CEACAM1 and HMGB1. The TIM-3-ligand axis is critical in the pathogenesis of numerous conditions, including autoimmune diseases, infections, cancers, transplant rejection, and chronic inflammation [1] [2] [3] [4] [5] . TIM-3/HAVCR2 Protein, Human (HEK293, His) is the recombinant human-derived TIM-3/HAVCR2 protein, expressed by HEK293 , with C-6*His labeled tag.

Human

T cell immunoglobulin mucin-3 (TIM-3) belongs to the Ig superfamily. TIM-3 is usually expressed by multiple murine and human immune cell types. TIM-3 was first discovered on IFN-γ producing Th1 and Tc1 cells. TIM-3 acts as an inhibitory receptor, and inhibits T cell functions. TIM-3 is associated with the regulation of immune responses in autoimmunity and cancer [1] [5] . TIM-3 has multiple different ligands: galectin 9, phosphatidylserine (PtdSer), CEACAM1 and HMGB1, and these ligands bind to different regions on the TIM3 extracellular immunoglobulin V domain. The TIM-3-ligand axis is critical in the pathogenesis of numerous conditions, including autoimmune diseases, infections, cancers, transplant rejection, and chronic inflammation. For example, the binding of TIM-3 with galectin-9 can downregulate Th1 responses [2] [3] [4] . Inaddition, dysregulation of Tim-3 expression is associated with autoimmune diseases [5] .

Hepatitis A Virus Cellular Receptor 2; HAVcr-2; T-Cell Immunoglobulin and Mucin Domain-Containing Protein 3; TIMD-3; T-Cell Membrane Protein 3; TIM-3; HAVCR2; TIM3; TIMD3

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

Room temperature in continental US; may vary elsewhere.