protein

GAS6 Protein, Human (HEK293, Fc)

HY-P70470

10 μg;50 μg;100 μg

135;380;645 USD

GAS6 Protein, Human (HEK293, Fc)

proteins

HEK293

10 μg;50 μg;100 μg

135;380;645 USD

GAS6 Protein is a secreted protein located outside the cell membrane. GAS6 Protein is a ligand for tyrosine protein kinase receptors AXL, TYRO3, and MER, and its signal transduction is related to cell growth and survival, cell adhesion, and cell migration. GAS6 is associated with tumor cell growth, metastasis, invasion, epithelial mesenchymal transition, angiogenesis, drug resistance, immune regulation, and stem cell maintenance after binding to AXL. GAS6 Protein, Human (HEK293, Fc) is a recombinant GAS6 protein with an Fc tag, expressed by HEK293 [1] [2] .

Human

GAS6 Protein is encoded by the growth arrest-specific gene 6 (Gas6) and belongs to the vitamin K-dependent protein family [2] . GAS6 Protein-AXL can regulate various signaling pathways like PI3K/AKT/mTOR, JAK/STAT, NF-κB, and RAS/RAF/MEK/ERK. It plays a role in tumor cell survival, anti-apoptotic signaling, mitosis, migration, invasion, drug resistance, angiogenesis, and the tumor-host relationship [2] . GAS6 Protein-AXL can promote the survival of endothelial cells, regulate the optimal cytokine signaling during the development of human natural killer cells, support liver regeneration, assist the survival and migration of gonadotropin-releasing hormone neurons, and facilitate platelet activation or thrombotic responses; it can also induce actin remodeling, driving membrane folding, giant cell phagocytosis, and cancer cell invasion [1] [3] . GAS6 Protein signaling plays a beneficial role in septic heart conditions by inhibiting inflammation, oxidative stress, mitochondrial damage, and ER stress, with NLRP3 being the main molecule mediating GAS6 signaling [4] . GAS6 Protein mediates the binding of viruses to target cells by bridging the phosphatidylserine on the viral particle to the TAM receptor tyrosine kinase AxI on the target cell, facilitating viral entry [5] . GAS6 Protein is closely related to pathological processes like nephritis, tumors, viral infections, and cardiovascular diseases [1] [4] [5] .

AXLLG; AXLLGAXL stimulatory factor; AXSFAXL receptor tyrosine kinase ligand; Gas6; GAS-6; growth arrest-specific 6; growth arrest-specific protein 6

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.