protein

Wnt3a Protein, Mouse (His)

HY-P70452

10 μg;50 μg;100 μg

140;350;560 USD

Wnt3a Protein, Mouse (His)

proteins

E. coli

10 μg;50 μg;100 μg

140;350;560 USD

Wnt-3a protein is a Frizzled receptor ligand that activates TCF/LEF transcription factors in the canonical Wnt pathway, which is critical for embryonic mesoderm development, somite formation, neural tube morphogenesis, and stem cell self-renewal in vitro. Formation of a 1:1 complex with AFM ensures prolonged biological activity and may represent its physiological form. Wnt3a Protein, Mouse (His) is the recombinant mouse-derived Wnt3a, expressed by E. coli , with N-10*His labeled tag. ,

Mouse

The Wnt-3a protein functions as a ligand for members of the frizzled family of seven transmembrane receptors, likely operating in the canonical Wnt signaling pathway, leading to the activation of transcription factors of the TCF/LEF family. It is crucial for normal embryonic mesoderm development, the formation of caudal somites, and the morphogenesis of the developing neural tube. Wnt-3a plays a key role in mediating the self-renewal of stem cells at the base of intestinal crypts in vitro. Additionally, the protein forms a soluble 1:1 complex with AFM, preventing oligomerization and ensuring prolonged biological activity; this complex may represent the physiological form in body fluids. As a homooligomer, Wnt-3a is disulfide-linked, leading to inactivation. It interacts with APCDD1, WLS, LRP6, PORCN, glypican GPC3, and PKD1, highlighting its involvement in diverse signaling and developmental processes.

Wnt-3a; Wnt 3a; WNT3A protein; Wnt3a

Greater than 90 % as determined by reducing SDS-PAGE.

Lyophilized from a 0.22 μm filtered solution of PBS, 6% Trehalose, pH 7.4.

Room temperature in continental US; may vary elsewhere.