protein

RANTES/CCL5 Protein, Human

HY-P70450

10 μg;50 μg;100 μg;500 μg

100;280;475;1250 USD

RANTES/CCL5 Protein, Human

proteins

E. coli

10 μg;50 μg;100 μg;500 μg

100;280;475;1250 USD

RANTES/CCL5 Protein is a secreted protein located outside the cell membrane and is a key pro-inflammatory chemokine and immune regulatory molecule in the CC chemokine family. RANTES/CCL5 Protein sends signals through its specific G protein-coupled receptors (GPCR) CCR1, CCR3, and CCR5, mediating inflammatory immune responses, viral infections, and tumor development. RANTES/CCL5 Protein can promote endothelial cell migration, proliferation, and angiogenesis in rats. RANTES/CCL5 Protein is useful for research into tumors, autoimmune diseases, and atherosclerosis. RANTES/CCL5 Protein, Human is a recombinant human CCL5 (S24-S91) protein expressed by E. coli [1] [2] .

Human

CCL5, also known as RANTES (Regulated upon Activation, Normal T Cell Expressed and Secreted), is part of the CC subfamily of chemokines. The CCL5 gene is located in the q11.2-q12 region of human chromosome 17 and encodes a CCL5 protein with a molecular weight of 8 kDa [1] . RANTES/CCL5 Protein can be secreted by many cell types, such as platelets, endothelial cells, smooth muscle cells, macrophages, and activated T cells [1] . RANTES/CCL5 Protein can induce the expression of MMP-1 and MMP-13 in human rheumatoid arthritis synovial fibroblasts by utilizing heparan sulfate proteoglycans (HSPGs) and/or selectively activating PKCδ, JNK, and ERK proteins in the PKCδ-JNK/ERK pathway, ultimately leading to collagen degradation [3] . RANTES/CCL5 Protein promotes angiogenesis by binding to GPCR, CCR1, and CCR5, as well as to its proteoglycan receptors SDC-1, SDC-4, and CD-44, and it partially relies on VEGF secreted by endothelial cells [1] . RANTES/CCL5 Protein is induced by the relevant cytokine IL-13 in mice infected with RSV, leading to airway hyperreactivity (AHR) and worsening airway diseases [4] . RANTES/CCL5 Protein interacts with CCR5, increasing the phosphorylation of MEK and ERK in the MEK/ERK pathway, activating NF-κB, leading to the activation of αvβ3 integrin and promoting the migration of human osteosarcoma cells [5] . The oligomeric form of RANTES/CCL5 Protein is important for some of its functions. RANTES/CCL5 Protein can form larger aggregates in neutral pH environments, while it forms smaller aggregates when the pH is lowered [6] . RANTES/CCL5 Protein is associated with various pathological processes, including viral infections, atherosclerosis, inflammatory diseases, autoimmune diseases, and tumors [1] .

C-C Motif Chemokine 5; EoCP; Eosinophil Chemotactic Cytokine; SIS-Delta; Small-Inducible Cytokine A5; T Cell-Specific Protein P228; TCP228; T-Cell-Specific Protein RANTES; CCL5; D17S136E; SCYA5

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 20 mM Citrate, 6% Trehalose, 4% Mannitol, 0.05% Tween 80, pH 4.0 or 4mM HCL, pH 2.5 or PBS, pH 7.4, 8% trehalose.

Room temperature in continental US; may vary elsewhere.