protein

FGF-2 Protein, Mouse (154a.a)

HY-P70439

2 μg;10 μg;50 μg;100 μg;500 μg

30;50;120;200;500 USD

FGF-2 Protein, Mouse (154a.a)

proteins

E. coli

2 μg;10 μg;50 μg;100 μg;500 μg

30;50;120;200;500 USD

FGF-2 protein is a member of the fibroblast growth factor family, involved in biological processes such as bone healing, cartilage repair, tumor development, and nerve regeneration. FGF-2 is also a mitogen that accelerates cell proliferation. It regulates immune processes by specifically targeting tyrosine kinase receptors and activating the FGF/FGFR signaling pathway. FGF-2 protein, Mouse (154 a.a.), is a recombinant protein produced in E. coli (Escherichia coli), consisting of 154 amino acids (M1-S154), and is untagged [1] [2] [3] [4] [5] [6] [7] [8] [9] .

Mouse

FGF-2 protein belongs to the heparin-binding FGF growth factor family and plays a crucial role in tendon-to-bone healing, cartilage repair, bone repair, nerve regeneration, and cancer development [1] [4] . (1) Bone Cell Proliferation: Low doses of FGF-2 protein stimulate the proliferation and differentiation of bone marrow mesenchymal stem cells and upregulate the mRNA expression of type I/III collagen and fibronectin. However, high doses of FGF-2 protein do not stimulate extracellular matrix (ECM) protein proliferation and gene expression. FGF-2 protein also acts as an endogenous and intrinsic growth factor in cartilage repair. FGF-2 binds to heparan sulfate proteoglycans and is stored in the ECM of articular cartilage. When cartilage is damaged or degenerates, ECM rapidly releases FGF-2 and activates ERK signaling pathways to promote cartilage regeneration. FGF-2 exhibits a biphasic effect when binding to its specific receptors. FGF-2 promotes the repair of articular cartilage in conjunction with FGFR3, whereas it promotes the degeneration of articular cartilage when combined with FGFR1 [1] . (2) Inducing Cancer Development: FGF-2 enhances the self-renewal of glioblastoma stem cells, contributing to glioma growth and vascularization [2] . Dysregulation of FGF-2 signaling induces cancer development, and FGF-2 protein is a key tumor-promoting factor in the tumor microenvironment [6] . (3) Neurogenesis: FGF-2 protein is essential for the proliferation of cortical cells and neurogenesis in the brain [3] . FGF-2 protein regulates the proliferation and differentiation of neural stem cells through β-catenin mediation. In the presence of FGF-2 protein, overexpression of β-catenin helps maintain neural progenitor cells in a proliferative state. However, in the absence of FGF-2 protein, overexpression of β-catenin enhances neuronal differentiation [8] . (4) Inducing Inflammation: Elevated levels of FGF-2 protein lead to dysregulation of angiogenesis and inflammatory responses, inducing the expression of various inflammation-related genes, including pro-inflammatory cytokines/chemokines and their receptors, endothelial cell adhesion molecules, and components of the prostaglandin pathway [4] . (5) Angiogenesis: FGF-2 protein promotes angiogenesis by interacting with various endothelial cell surface receptors, including tyrosine kinase receptors, heparan sulfate proteoglycans, and integrins [4] . Overexpression of FGF-2 protein in vivo leads to pulmonary arterial smooth muscle cell (SMC) proliferation, while a reduction in FGF-2 protein levels effectively prevents pulmonary arterial hypertension [7] . FGF-2 protein is highly conserved among certain species, with human FGF-2 protein sequence sharing 97.4%, 95.45%, and 98.71% similarity with that of rat, mouse, and cow, respectively.

Fibroblast Growth Factor 2; FGF-2; Basic Fibroblast Growth Factor; bFGF; Heparin-Binding Growth Factor 2; HBGF-2; Fgf2; Fgf-2

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 400 mM NaCl, 0.02% Tween 80, 4.0% Sucrose, 4.0% Manntiol, pH 7.0 or PBS, pH 7.4, 8% trehalose or 20mM PB,0.02% Tween 80,2.0% Sucrose,4.0% Manntiol,pH 7.0.

Room temperature in continental US; may vary elsewhere.