protein

Neuropilin-1 Protein, Mouse (HEK293, His)

HY-P70401

10 μg;50 μg

80;240 USD

Neuropilin-1 Protein, Mouse (HEK293, His)

proteins

HEK293

10 μg;50 μg

80;240 USD

Neuropilin-1 protein is an important receptor critical for cardiovascular system development, angiogenesis, neuronal circuit formation, and non-nervous system organogenesis.It mediates the chemical pulse activity of signaling proteins, recognizes C-terminal regular motifs on ligands, and promotes cellular internalization and vascular leakage.Neuropilin-1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Neuropilin-1 protein, expressed by HEK293 , with C-6*His labeled tag.

Mouse

Neuropilin-1 Protein serves as a receptor crucial for the development of the cardiovascular system, angiogenesis, the formation of specific neuronal circuits, and organogenesis outside the nervous system. Functioning as a mediator of semaphorins' chemorepulsant activity, it recognizes the C-end rule (CendR) motif R/KXXR/K on its ligands, facilitating cellular internalization and vascular leakage. Neuropilin-1 binds to semaphorin 3A (SEMA3A), the PLGF-2 isoform of PGF, and the VEGF165 isoform of VEGFA and VEGFB. Coexpression with KDR enhances VEGF165 binding to KDR and increases chemotaxis. The protein regulates VEGF-induced angiogenesis and initiates a signaling pathway crucial for motor neuron axon guidance and cell body migration during embryonic development. Additionally, Neuropilin-1 plays a role in regulating mitochondrial iron transport through interaction with ABCB8/MITOSUR. It forms homodimers and heterodimers with NRP2, binds PLXNB1, and interacts with FER, VEGFA, and ABCB8/MITOSUR in mitochondria.

rMuNeuropilin-1, His; CD304; NRP1; NRPNP1; VEGF165R; BDCA4; Neuropilin-1

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US;may vary elsewhere.