protein

Grb2 Protein, Human (His)

HY-P70396

5 μg;10 μg;20 μg;50 μg

72;115;185;350 USD

Grb2 Protein, Human (His)

proteins

E. coli

5 μg;10 μg;20 μg;50 μg

72;115;185;350 USD

Grb2, an adapter protein, crucially connects cell surface growth factor receptors to the Ras signaling pathway. Despite no direct binding to phosphorylated EGFR, Grb2 inhibits EGF-induced transactivation of a RAS-responsive element. It acts as a dominant negative relative to GRB2, suppressing proliferative signals and potentially initiating programmed cell death. Grb2 Protein, Human (His) is the recombinant human-derived Grb2 protein, expressed by E. coli , with C-6*His labeled tag.

Human

Grb2, an adapter protein, plays a pivotal role in establishing a crucial connection between cell surface growth factor receptors and the Ras signaling pathway. Despite its lack of direct binding to phosphorylated epidermal growth factor receptor (EGFR), Grb2 exerts an inhibitory effect on EGF-induced transactivation of a RAS-responsive element. Notably, Grb2 functions as a dominant negative protein relative to GRB2, suppressing proliferative signals and potentially instigating active programmed cell death.

rHuGrowth factor receptor-bound protein 2/GRB2, His; Growth Factor Receptor-Bound Protein 2; Adapter Protein GRB2; Protein Ash; SH2/SH3 Adapter GRB2; GRB2; ASH

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 6% Sucrose, 4% Mannitol, 50 mM NaCl, 0.05% Tween 80, pH 8.0 or 50 mM Tris-HCL, 150 mM NaCl, pH 8.0, 8% trehalose, 0.02% Tween 80.

Room temperature in continental US; may vary elsewhere.