protein

HLA-A*0201 HPV16 E7 complex Protein, Human (YMLDLQPET, HEK293, His)

HY-P70393

10 μg;50 μg

95;285 USD

HLA-A*0201 HPV16 E7 complex Protein, Human (YMLDLQPET, HEK293, His)

proteins

HEK293

10 μg;50 μg

95;285 USD

B2M is a component of MHC class I complexes that present peptide antigens to the immune system. HLA-A*0201 HPV16 E7 complex Protein, Human (YMLDLQPET, HEK293, His) is a recombinant protein dimer complex containing human-derived HLA-A*0201 HPV16 E7 complex protein, expressed by HEK293 , with C-10*His labeled tag.

Human

B2M, or Beta-2-microglobulin, functions as a critical component of the class I major histocompatibility complex (MHC), playing a central role in presenting peptide antigens to the immune system. Notably, exogenously applied M. tuberculosis EsxA or EsxA-EsxB binds B2M and reduces its export to the cell surface, potentially leading to defects in class I antigen presentation. B2M exists as a heterodimer, composed of an alpha chain and a beta chain, with the latter serving as the beta-chain of major histocompatibility complex class I molecules. Polymers of B2M have been observed in tissues of patients on long-term hemodialysis. B2M, in its isolated form, interacts with M. tuberculosis EsxA and an EsxA-EsxB complex, forming a tripartite complex detectable in the host endoplasmic reticulum. The stability of the B2M-EsxA complex extends across a broad pH range and in the presence of high salt concentrations. Additionally, B2M forms heterotrimers with HLA-E, HLA-G, and HLA-F, along with a self- or foreign peptide, contributing to the diverse functions of the major histocompatibility complex. Furthermore, B2M engages in a heterotrimeric complex with MR1, playing a role in antigen presentation associated with metabolite antigens.

rHuHLA-A*0201 HPV16 E7 complex Protein, His; NA

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 500 mM NaCl, 0.06% Tween 80, pH 7.4.

Room temperature in continental US;may vary elsewhere.