protein

Ribonuclease UK114/HRSP12 Protein, Human (His)

HY-P70372

10 μg;50 μg

90;270 USD

Ribonuclease UK114/HRSP12 Protein, Human (His)

proteins

E. coli

10 μg;50 μg

90;270 USD

The ribonuclease UK114/HRSP12 protein catalyzes the hydrolytic deamination of enamine/imine intermediates, reducing the potential toxicity of these reactive metabolites by releasing ammonia. Ribonuclease UK114/HRSP12 Protein, Human (His) is the recombinant human-derived Ribonuclease UK114/HRSP12 protein, expressed by E. coli , with N-6*His labeled tag. The total length of Ribonuclease UK114/HRSP12 Protein, Human (His) is 137 a.a., with molecular weight of 14-16 kDa.

Human

Ribonuclease UK114/HRSP12 protein plays a crucial role in cellular metabolism by catalyzing the hydrolytic deamination of enamine/imine intermediates that arise during normal metabolic processes. This enzymatic activity is thought to facilitate the safe release of ammonia from these potentially toxic reactive metabolites, thereby mitigating their impact on cellular components. HRSP12 is particularly associated with enamine/imine intermediates formed by various pyridoxal-5'-phosphate-dependent dehydratases, including L-threonine dehydratase. Moreover, it contributes to endoribonucleolytic cleavage of specific transcripts by promoting the recruitment of the ribonuclease P/MRP complex. Acting as a bridge between YTHDF2 and the ribonuclease P/MRP complex, HRSP12 binds to N6-methyladenosine (m6A)-containing mRNAs featuring a 5'-GGUUC-3' motif. The cooperative binding of HRSP12 and YTHDF2 to such transcripts leads to the recruitment of the ribonuclease P/MRP complex, facilitating subsequent endoribonucleolytic cleavage.

rHuRibonuclease UK114/HRSP12, His; Ribonuclease UK114; 14.5 kDa Translational Inhibitor Protein; p14.5; Heat-Responsive Protein 12; UK114 Antigen Homolog; HRSP12; PSP

Greater than 95% as determined by reducing SDS-PAGE.

Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 100 mM NaCl, 1 mM DTT, 10% Glycerol, pH 8.0.

Shipping with dry ice