protein

MeCP2 Protein, Human (HEK293, His)

HY-P70366

10 μg;50 μg

170;510 USD

MeCP2 Protein, Human (HEK293, His)

proteins

HEK293

10 μg;50 μg

170;510 USD

The MeCP2 protein is a chromosome binder that specifically binds to methylated DNA independent of flanking sequences. MeCP2 Protein, Human (HEK293, His) is the recombinant human-derived MeCP2 protein, expressed by HEK293 , with C-6*His labeled tag.

Human

The MeCP2 protein functions as a chromosomal entity with a distinctive ability to bind specifically to methylated DNA, targeting individual methyl-CpG pairs independently of flanking DNA sequences. Operating as a mediator of transcriptional repression, MeCP2 engages in interactions with histone deacetylase and the corepressor SIN3A. Moreover, it demonstrates dual binding capabilities, associating with both 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC)-containing DNA, exhibiting a notable preference for 5-methylcytosine (5mC). The versatility of MeCP2 is further emphasized by its interactions with FNBP3, CDKL5, ATRX, NCOR2, TBL1XR1, and TBL1X, each interaction contributing to various cellular processes, including the recruitment of co-repressor complexes and the orchestration of heterochromatin organization. This multifaceted functionality underscores the pivotal role of MeCP2 in epigenetic regulation and the modulation of gene expression.

rHuMethyl-CpG-binding protein 2/MECP2, His; Methyl-CpG-binding protein 2; MECP2; MeCp-2 protein

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 20 mM Tris, 300 mM NaCl, 5% Trehalose, 2 mM DTT, pH 8.0 or 20 mM Histidine-HCl, 8% Sucrose, 50mM NaCl, 0.02% Tween 80, pH 6.0

Room temperature in continental US; may vary elsewhere.