protein

METAP2/Methionine aminopeptidase 2 Protein, Human (Sf9, His)

HY-P70364

10 μg;50 μg;100 μg;500 μg

110;310;500;1250 USD

METAP2/Methionine aminopeptidase 2 Protein, Human (Sf9, His)

proteins

Sf9 insect cells

10 μg;50 μg;100 μg;500 μg

110;310;500;1250 USD

METAP2/Methionine aminopeptidase 2 protein removes N-terminal methionine from nascent proteins. It preferentially cleaves when the second residue is small and uncharged. METAP2 has higher catalytic activity for Met-Val peptides than METAP1, suggesting its role in processing Met-Val and Met-Thr sequences in vivo. It also protects EIF2S1 from phosphorylation by inhibitory kinases, regulating protein synthesis. METAP2/Methionine aminopeptidase 2 Protein, Human (Sf9, His) is the recombinant human-derived METAP2/Methionine aminopeptidase 2 protein, expressed by Sf9 insect cells , with N-6*His labeled tag.

Human

METAP2/Methionine aminopeptidase 2 protein functions by cotranslationally removing the N-terminal methionine from nascent proteins. This N-terminal methionine cleavage occurs when the second residue in the primary sequence is small and uncharged, such as Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val. The catalytic activity of human METAP2 towards Met-Val peptides is significantly higher than that of METAP1, suggesting its responsibility for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo. In addition, METAP2 protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases like EIF2AK2/PKR and EIF2AK1/HCR, thus playing a critical role in regulating protein synthesis.

rHuMethionine aminopeptidase 2/METAP2, His; Methionine aminopeptidase 2; MAP 2; MetAP 2; p67; p67eIF2; Peptidase M; METAP2; MAP2

Greater than 95% as determined by reducing SDS-PAGE.

Supplied as a 0.2 μm filtered solution of 20 mM Tris, 500 mM NaCl, 10% Glycerol, pH 8.0.

Shipping with dry ice