protein

IGFBP-6 Protein, Mouse (HEK293, His)

HY-P70357

10 μg;50 μg

107;300 USD

IGFBP-6 Protein, Mouse (HEK293, His)

proteins

HEK293

10 μg;50 μg

107;300 USD

IGFBP-6 protein can extend the half-life of IGF and regulate its effects. It can inhibit or stimulate the growth-promoting effects of IGF. IGFBP-6 Protein, Mouse (HEK293, His) is the recombinant mouse-derived IGFBP-6 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of IGFBP-6 Protein, Mouse (HEK293, His) is 213 a.a., with molecular weight of ~28.0 kDa.

Mouse

IGFBP-6 protein assumes a pivotal role in regulating the activity of insulin-like growth factors (IGFs) by extending their half-life. In cell culture, IGFBP-6 has been demonstrated to exert a dual regulatory influence, capable of either inhibiting or stimulating the growth-promoting effects of IGFs. This versatile function underscores the complexity of IGFBP-6 in modulating cellular processes. Furthermore, IGFBP-6 plays a role in altering the interaction between IGFs and their cell surface receptors. Beyond its role in IGF regulation, IGFBP-6 actively participates in cellular signaling by activating the MAPK pathway and inducing cell migration. Notably, it interacts with PHB2 via its C-terminal domain, highlighting its involvement in intricate protein-protein interactions that contribute to the multifaceted cellular responses associated with growth regulation and migration.

rMuInsulin-like growth factor-binding protein 6/IGFBP-6, His; Insulin-like growth factor-binding protein 6; IBP-6; IGF-binding protein 6; IGFBP-6; Igfbp6; IBP6; IGF binding protein 6; insulin-like growth factor-binding protein 6

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US;may vary elsewhere.