protein

nAChRα5 Protein, Human (HEK293, His)

HY-P70340

10 μg;50 μg

140;400 USD

nAChRα5 Protein, Human (HEK293, His)

proteins

HEK293

10 μg;50 μg

140;400 USD

The nAChRα5 protein induces significant conformational changes in all subunits upon acetylcholine binding, leading to the opening of ion-conducting channels in the plasma membrane. nAChRα5, composed of α and non-α (β) subunits, interacts with LYPD6 to reveal complex regulatory mechanisms in neuronal acetylcholine receptors. nAChRα5 Protein, Human (HEK293, His) is the recombinant human-derived nAChRα5 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of nAChRα5 Protein, Human (HEK293, His) is 232 a.a., with molecular weight of 35-40 kDa.

Human

Upon acetylcholine binding, nAChRα5 Protein initiates a substantial conformational change that influences all subunits, ultimately resulting in the opening of an ion-conducting channel across the plasma membrane. The neuronal AChR is evidently comprised of two distinct types of subunits: the alpha subunits and the non-alpha (beta) subunits. Notably, nAChRα5 Protein engages in interactions with LYPD6, as documented in studies. This molecular interaction sheds light on the intricate regulatory mechanisms underlying the functionality of neuronal acetylcholine receptors, emphasizing the dynamic nature of their conformational changes and their significance in ion channel activation.

rHuNeuronal acetylcholine receptor subunit alpha-5/NACHRA5, His; Neuronal Acetylcholine Receptor Subunit Alpha-5; CHRNA5; NACHRA5

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US;may vary elsewhere.