protein

HSP40/DNAJB1 Protein, Human (His)

HY-P70331

10 μg;50 μg

110;330 USD

HSP40/DNAJB1 Protein, Human (His)

proteins

E. coli

10 μg;50 μg

110;330 USD

HSP40/DNAJB1 protein, a key player in cellular processes, interacts with HSP70 to enhance ATPase activity and stimulate HSC70-HIP association. It negatively regulates HSF1 transcriptional activity in heat shock response recovery, and interacts with DNAJC3 and HSF1, inhibiting their transcriptional activity. These multifaceted interactions showcase HSP40/DNAJB1's intricate regulatory functions in stress responses and protein folding. HSP40/DNAJB1 Protein, Human (His) is the recombinant human-derived HSP40/DNAJB1 protein, expressed by E. coli , with C-6*His labeled tag.

Human

The HSP40/DNAJB1 protein plays a crucial role in cellular processes through its interactions with various partners. It interacts with HSP70, enhancing its ATPase activity and stimulating the association between HSC70 and HIP. Moreover, HSP40/DNAJB1 negatively regulates the transcriptional activity of HSF1 during the attenuation and recovery phase of the heat shock response, demonstrating its role in modulating heat shock-induced processes. Additionally, HSP40/DNAJB1 interacts with DNAJC3 and HSF1, inhibiting their transcriptional activity during the recovery phase of the heat shock response. These interactions highlight the multifaceted nature of HSP40/DNAJB1 in orchestrating cellular responses to stress and protein folding, shedding light on its intricate regulatory functions.

rHuDnaJ homolog subfamily B member 1/HSP40, His; DnaJ Homolog Subfamily B Member 1; DnaJ Protein Homolog 1; Heat Shock 40 kDa Protein 1; HSP40; Heat Shock Protein 40; Human DnaJ Protein 1; hDj-1; DNAJB1; DNAJ1; HDJ1; HSPF1

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, 1 mM EDTA, pH 7.4.

Room temperature in continental US; may vary elsewhere.