protein

MAG/Siglec-4a Protein, Mouse (HEK293, His, solution)

HY-P70319A

10 μg;50 μg

80;225 USD

MAG/Siglec-4a Protein, Mouse (HEK293, His, solution)

proteins

HEK293

10 μg;50 μg

80;225 USD

MAG/Siglec-4a protein mediates myelin cell-neuron interactions by binding to gangliosides, RTN4R, and RTN4RL2. It maintains normal axonal myelination and protects motor neurons from apoptosis following injury. MAG/Siglec-4a Protein, Mouse (HEK293, His, solution) is the recombinant mouse-derived MAG/Siglec-4a protein, expressed by HEK293 , with C-6*His labeled tag. The total length of MAG/Siglec-4a Protein, Mouse (HEK293, His, solution) is 497 a.a., with molecular weight of 70-120 kDa.

Mouse

The MAG/Siglec-4a protein is an adhesion molecule that plays a crucial role in mediating interactions between myelinating cells and neurons. It achieves this by binding to neuronal gangliosides containing sialic acid and to the glycoproteins RTN4R and RTN4RL2. While it is not necessary for initial myelination, it is involved in maintaining normal axon myelination. Additionally, it offers protection against apoptosis in motoneurons, particularly after injury, likely through its interaction with neuronal RTN4R and RTN4RL2. In adults, it is essential for preventing the degeneration of myelinated axons, and this process is likely dependent on its binding to gangliosides on the axon cell membrane. Moreover, the MAG/Siglec-4a protein acts as a negative regulator of neurite outgrowth by inhibiting axon growth longitudinally. Its inhibitory effects on neurite extension are mediated primarily through its interaction with neuronal RTN4R, RTN4RL2, and gangliosides. It binds preferentially to alpha-2,3-linked sialic acid and ganglioside Gt1b. The MAG/Siglec-4a protein can exist as a monomer or homodimer and interacts with isoform 2 of BSG through its first three N-terminal Ig-like domains.

rMuMyelin-associated glycoprotein/MAG, His; Myelin-Associated Glycoprotein; MAG; Siglec-4a

Greater than 95% as determined by reducing SDS-PAGE.

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

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