protein

Elafin/Trappin-2 Protein, Human (HEK293, His)

HY-P70316

10 μg;50 μg

170;475 USD

Elafin/Trappin-2 Protein, Human (HEK293, His)

proteins

HEK293

10 μg;50 μg

170;475 USD

Elafin/Trappin-2, a skin-specific inhibitor of neutrophil and pancreatic elastase, safeguards tissues against elastase-mediated proteolysis. Its inhibitory range extends to the alpha-4-beta-2/CHRNA2-CHRNB2 nicotinic acetylcholine receptor. Elafin/Trappin-2 also weakly inhibits Kv11.1/KCNH2/ERG1 and transient receptor potential cation channel subfamily V member 1 (TRPV1), as reported in studies. Elafin/Trappin-2 Protein, Human (HEK293, His) is the recombinant human-derived Elafin/Trappin-2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of Elafin/Trappin-2 Protein, Human (HEK293, His) is 95 a.a., with molecular weight of 13-15 kDa.

Human

Elafin/Trappin-2, identified as a neutrophil and pancreatic elastase-specific inhibitor primarily found in the skin, serves as a protective factor against elastase-mediated tissue proteolysis. Its inhibitory properties extend beyond proteases, as it has demonstrated the ability to inhibit the alpha-4-beta-2/CHRNA2-CHRNB2 nicotinic acetylcholine receptor. Additionally, Elafin/Trappin-2 exerts a weak inhibitory effect on Kv11.1/KCNH2/ERG1 and the transient receptor potential cation channel subfamily V member 1 (TRPV1), as documented in studies.

rHuElafin, His; Elafin; Elastase-Specific Inhibitor; ESI; Peptidase Inhibitor 3; PI-3; Protease inhibitor WAP3; Skin-Derived Antileukoproteinase; SKALP; WAP Four-Disulfide Core Domain Protein 14; PI3; WAP3; WFDC14

Greater than 95% as determined by reducing SDS-PAGE.

Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl, pH 7.5.

Shipping with dry ice.