protein

NME1/NDPKA Protein, Human (His)

HY-P70299

10 μg;50 μg

150;420 USD

NME1/NDPKA Protein, Human (His)

proteins

E. coli

10 μg;50 μg

150;420 USD

The NME1/NDPKA protein plays a crucial role in the synthesis of nucleoside triphosphates and exhibits multiple activities, including nucleoside diphosphate kinase, serine/threonine-specific protein kinase, geranyl and farnesyl pyrophosphate kinase, histidine protein kinase and 3'-5' exonuclease functions. NME1/NDPKA Protein, Human (His) is the recombinant human-derived NME1/NDPKA protein, expressed by E. coli , with N-6*His labeled tag.

Human

NME1/NDPKA Protein plays a major role in synthesizing nucleoside triphosphates, excluding ATP. It utilizes a ping-pong mechanism, transferring the ATP gamma phosphate to the NDP beta phosphate via a phosphorylated active-site intermediate. The protein exhibits diverse activities, including nucleoside-diphosphate kinase, serine/threonine-specific protein kinase, geranyl/farnesyl pyrophosphate kinase, histidine protein kinase, and 3'-5' exonuclease. NME1 is crucial for cell proliferation, differentiation, development, signal transduction, G protein-coupled receptor endocytosis, and gene expression. It is essential for neural development, impacting neural patterning and cell fate determination. In GZMA-mediated cell death, NME1 collaborates with TREX1, nicking one DNA strand and enhancing DNA damage to prevent rapid repair and reannealing.

rHuNucleoside diphosphate kinase A/NDPKA, His; Nucleoside Diphosphate Kinase A; NDK A; NDP Kinase A; Granzyme A-Activated DNase; GAAD; Metastasis Inhibition Factor nm23; Tumor Metastatic Process-Associated Protein; nm23-H1; NME1; NDPKA; NM23

Greater than 90% as determined by reducing SDS-PAGE.

Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 1 mM DTT, 10% Glycerol, pH 7.5.

Shipping with dry ice