protein

Histatin-3/HTN3 Protein, Human

HY-P70298

10 μg;50 μg

180;500 USD

Histatin-3/HTN3 Protein, Human

proteins

E. coli

10 μg;50 μg

180;500 USD

The Histatin-3/HTN3 protein is a key salivary component and a major precursor in the formation of the enamel film on the tooth surface. In addition to its structural role, histatin-3 also exhibits antibacterial and antifungal activity, particularly through its His3-(20-43)-peptide (histatin-5). Histatin-3/HTN3 Protein, Human is the recombinant human-derived Histatin-3/HTN3 protein, expressed by E. coli , with tag free. The total length of Histatin-3/HTN3 Protein, Human is 32 a.a., with molecular weight of 10-12 kDa.

Human

Histatin-3/HTN3 Protein, a vital component of salivary proteins, plays a crucial role as a major precursor in the formation of the protective proteinaceous structure on tooth surfaces, known as the enamel pellicle. Beyond its structural function, histatin-3 exhibits notable antibacterial and antifungal activities, with its His3-(20-43)-peptide (histatin-5) demonstrating particular efficacy against C. albicans and C. neoformans, while also inhibiting Lys-gingipain and Arg-gingipain (rgpB) from P. gingivalis. This peptide additionally serves as a potent inhibitor of metalloproteinases MMP2 and MMP9. Intriguingly, the His3-(20-43)-peptide exists as a homodimer. Histatin-3, along with its His3-(20-43)-peptide counterpart, interacts with yeast SSA1 and SSA2 proteins, emphasizing its multifaceted roles in host defense and oral health.

rHuHistatin-3/HTN3; Histatin-3; Basic histidine-rich protein; Histidine-rich protein 3; PB; HTN3.

Greater than 95% as determined by reducing SDS-PAGE.

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

Shipping with dry ice