protein

IL-1R1 Protein, Mouse (HEK293, His)

HY-P70286

10 μg;50 μg

100;280 USD

IL-1R1 Protein, Mouse (HEK293, His)

proteins

HEK293

10 μg;50 μg

100;280 USD

IL-1R1 (CD121a) belongs to IL-1 receptor, and binds to IL-1α, IL-1β, IL-1Ra and IL-38 with comparable affinities (K d : 0.1-1 nM) [1] . IL-1R1 regulates the transcription of multiple proinflammatory cytokines and mediates immune and inflammatory responses, including the activation of NF-κB and MAPK pathway [4] . IL-1R1 Protein, Mouse (HEK293, His) is a recombinant mouse extracellular region of IL-1R1 (L20-K338) with a C terminal 6*His tag, which is produced in HEK293 cells.

Mouse

IL-1R1 (CD121a), a member of IL-1 receptor, is a receptor for IL-1α, IL-1β, IL-1Ra and IL-38, thereby mediating IL-1-dependent activation [1] . IL-1R1 is mainly expressed in endothelial cells and astrocytes [2] . The sequence of amino acids in IL-1R1 differs in different species. Mouse IL-1R1 shares 85.59% aa sequence identity with rats, and shares IL-1R1 binds to IL-1 by forming a heterodimer with IL-1R3 (IL-1RAcP). The heterodimer is responsible for the signal transduction by the hydrolysis of GTP, followed by JNK and p38 MAP kinase [3] . Upon binding of IL-1, IL-1R1 initiates the downstream signaling cascade (MAPK p38 and NF-κB pathway) [4] . IL-1R1 also interacts with RIP1, RIP3, and MLKL, thereby induce the IL-1R1-necrosome complex formation and triggers Hemin-induced neuronal necroptosis in mice [5] . IL-1R1 mediates immune and inflammatory responses. IL-1R1 mediates the activation of NF-κB, MAPK pathway.

rMuInterleukin-1 receptor type 1/IL-1R1, His ; Interleukin-1 receptor type 1; IL-1R-1; IL-1RT1; IL-1 RI; CD121a

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.

Room temperature in continental US; may vary elsewhere.