protein

G6PD Protein, Human (HEK293, His)

HY-P70283

5 μg;10 μg;50 μg;100 μg;500 μg;1 mg

85;135;350;560;1230;1760 USD

G6PD Protein, Human (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg;100 μg;500 μg;1 mg

85;135;350;560;1230;1760 USD

The G6PD protein is a rate-limiting enzyme in the oxidative pentose phosphate pathway located in the cytosol, which is crucial for the catabolism of carbohydrates in glycolysis. The primary function of G6PD is to provide reducing power in the form of NADPH and generate pentose phosphates, helping the cell resist oxidative stress and regulate metabolic rates. Additionally, the activity of G6PD is associated with cancer progression. The G6PD protein (Human, HEK293, His) is a recombinant G6PD protein expressed in HEK293 cells, with a C-terminal His tag, and consists of 514 amino acids (A2-L515) [1] [2] [3] [4] [5] [6] [7] .

Human

G6PD is the first enzyme in the pentose phosphate pathway of glucose metabolism. By regulating the pentose phosphate pathway, G6PD maintains intracellular levels of reduced glutathione, helping cells resist oxidative stress. The G6PD protein is crucial for protecting red blood cells from oxidative stress; a deficiency in this enzyme can lead to hemolysis, neonatal jaundice, and favism [1] [2] . G6PD activity is closely related to oocyte development. As the oocyte completes its growth phase, the activity of G6PD significantly decreases, indicating its key role during the early stages of cell development [3] . G6PD is upregulated in various cancers and is associated with tumor development and resistance to chemotherapy. For instance, increased G6PD expression can inhibit apoptosis caused by oxidative stress in osteosarcoma (OS) tissues and cell lines (MG-63, SaoS-2, SJSA-1, G-292). G6PD also acts as an angiogenic factor, promoting angiogenesis, providing nutrients for tumor cells, and supporting tumor cell growth. Therefore, G6PD holds promise as a target for inhibiting tumor growth [4] .

rHuGlucose-6-phosphate 1-dehydrogenase/G6PD, His; Glucose-6-Phosphate 1-Dehydrogenase; G6PD

Greater than 95% as determined by reducing SDS-PAGE.

Supplied as a 0.2 μm filtered solution of 20mM Citrate, 15% Trehalose, 150mM NaCl, 0.05% Tween 80, pH5.5 or PBS, pH 7.4.

Shipping with dry ice