protein

Complement C3 Protein, Human (HEK293, His)

HY-P702819

20 μg;50 μg;100 μg

120;240;384 USD

Complement C3 Protein, Human (HEK293, His)

proteins

HEK293

20 μg;50 μg;100 μg

120;240;384 USD

Complement C3 protein activates the complement system, playing a central role in both classical and alternative pathways. C3b binds covalently to cell surface carbohydrates or immune aggregates, while C3a acts as an inflammatory mediator, inducing neutrophil chemoattraction and promoting smooth muscle contraction, increased vascular permeability, and histamine release. The shorter isoform of C3a stimulates B-cells. Complement C3 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Complement C3 protein, expressed by HEK293 , with C-His labeled tag. The total length of Complement C3 Protein, Mouse (HEK293, His) is 1639 a.a., with molecular weight of 65-68 kDa & 110-115 kDa & 165-180 kDa, respectively.

Human

Complement C3/C3a protein plays a pivotal role in the activation of the complement system, being the central reaction in both classical and alternative pathways. Following activation, C3b can bind covalently to cell surface carbohydrates or immune aggregates through its reactive thioester. C3a, derived from the proteolytic degradation of complement C3, acts as a local inflammatory mediator, inducing neutrophil chemoattraction and promoting smooth muscle contraction, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. Additionally, the shorter isoform of C3a exhibits B-cell stimulatory activity.

Complement C3; HSE-MSF; C3; CPAMD1; AHUS5; ARMD9; ASP; C3a; C3b; HEL-S-62p

Greater than 95% as determined by Tris-Bis PAGE.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Normally 8% trehalose is added as protectant before lyophilization.

Room temperature in continental US; may vary elsewhere.