protein

MBL2/COLEC1 Protein, Human (HEK293, His)

HY-P70281

10 μg;50 μg

80;220 USD

MBL2/COLEC1 Protein, Human (HEK293, His)

proteins

HEK293

10 μg;50 μg

80;220 USD

The MBL2/COLEC1 protein is a calcium-dependent lectin in innate immune defense that activates the lectin complement pathway by binding to mannose, fucose, and N-acetylglucosamine on microorganisms. MBL2/COLEC1 Protein, Human (HEK293, His) is the recombinant human-derived MBL2/COLEC1 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of MBL2/COLEC1 Protein, Human (HEK293, His) is 228 a.a., with molecular weight of ~31.0 kDa.

Human

MBL2, also known as COLEC1, is a calcium-dependent lectin actively involved in innate immune defense. This versatile protein binds to mannose, fucose, and N-acetylglucosamine on diverse microorganisms, initiating the lectin complement pathway. Furthermore, MBL2 exhibits a unique affinity for late apoptotic cells, apoptotic blebs, and necrotic cells, facilitating their efficient uptake by macrophages. Additionally, there is evidence suggesting its potential binding to DNA. In the context of SARS coronavirus-2 (SARS-CoV-2) infection, MBL2 plays a critical role in activating the complement lectin pathway, leading to the inhibition of SARS-CoV-2 infection and a reduction in the induced inflammatory response. Structurally, MBL2 forms oligomeric complexes composed of three or more homotrimers. Its functional interactions extend to MASP1, MASP2, MEP1A, MEP1B, and CR1, indicating its involvement in various regulatory and immune-related pathways.

rHuMannose-binding protein C/MBL-2, His; Mannose-Binding Protein C; MBP-C; Collectin-1; MBP1; Mannan-Binding Protein; Mannose-Binding Lectin; MBL2; COLEC1; MBL

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, 5% Threhalose, pH 7.2.

Room temperature in continental US; may vary elsewhere.