protein

IL-1 alpha Protein, Human

HY-P7027

2 μg;10 μg;50 μg;100 μg

48;120;300;480 USD

IL-1 alpha Protein, Human

proteins

E. coli

2 μg;10 μg;50 μg;100 μg

48;120;300;480 USD

375588478

IL-1 alpha is a ubiquitous and pivotal pro-inflammatory cytokine. IL-1 alpha is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. IL-1 alpha plays an important role in inflammation and bridges the innate and adaptive immune systems. IL-1 alpha mediates the activation of NF-kappa-B and the three MAPK pathways p38, p42/p44 and JNK pathways [1] [4] . IL-1 alpha protein, Human is a recombinant protein consisting of 159 amino acids (S113-A271) and is produced by E. coli.

Human

IL-1 alpha (interleukin-1 alpha) is a major agonist of IL-1. IL-1α is present in all mesenchymal cells in particular, cells rich in IL-1α constitute tissues with a barrier function, such as keratinocytes in the skin, type 2 epithelial cells in the lung, the epithelium of the entire gastrointestinal tract, endothelial cells in blood vessels, and astrocytes in the brain [1] . The precursor of IL-1α (ProIL-1α) is processed by the Ca 2+ -dependent protease calpain (including caspase-1) into the mature 17 kDa form and the 16 kDa N-terminal cleavage product – the propiece of IL-1α, also termed IL-1α N-terminal peptide (IL-1NTP). The latent form of calpain is activated in cells under inflammatory conditions and especially upon loss of plasma membrane integrity, which occurs during necrosis. pro-IL-1α and mature IL-1α bind to IL-1R and induces the secretion of IL-6 and TNF [5] . IL-1α acts as an ‘alarmin’ and as a primum movens of tissue inflammation [1] . IL-1 alpha trigger inflammation in a pathway initiated through Myd88 activation and culminated in NF-κB–induced transcription of inflammatory genes [2] . IL-1 alpha inhibits differentiation of preadipocytes and lipid accumulation [3] . IL-1 alpha induces apoptosis and inhibits the osteoblast differentiation [4] .

rHuIL-1α; Hematopoietin-1; IL1A; IL1F1; IL-1 alpha

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized after extensive dialysis against PBS, pH 7.4 or 20 mM Tris-HCl, 150 mM NaCl, pH 7.5 or 50 mM Tris-HCL, 300 mM NaCL, 200 mM arginine, pH 8.0 or PBS, pH 7.4, 8% trehalose.

Room temperature in continental US; may vary elsewhere.