protein

Myeloperoxidase/MPO Protein, Human (HEK293, His)

HY-P70255

5 μg;10 μg;50 μg

35;50;150 USD

Myeloperoxidase/MPO Protein, Human (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg

35;50;150 USD

The myeloperoxidase (MPO) protein is an important component of polymorphonuclear leukocytes and is critical for bactericidal activity in a variety of organisms. Upon leukocyte stimulation, MPO catalyzes the production of hypohalous acids (mainly hypochlorous acid), thereby enhancing bactericidal activity. Myeloperoxidase/MPO Protein, Human (HEK293, His) is the recombinant human-derived Myeloperoxidase/MPO protein, expressed by HEK293 , with C-His labeled tag.

Human

Myeloperoxidase (MPO) Protein constitutes a crucial component of the host defense system within polymorphonuclear leukocytes, playing a pivotal role in microbicidal activity against a diverse spectrum of organisms. Upon stimulation of polymorphonuclear leukocytes, MPO catalyzes the generation of hypohalous acids, predominantly hypochlorous acid under physiological conditions, along with other toxic intermediates that significantly enhance microbicidal activity in these cells. This enzymatic activity serves as a potent defense mechanism, contributing to the host's ability to combat various pathogens. Furthermore, MPO is implicated in the proteolytic cleavage of alpha-1-microglobulin, generating t-alpha-1-microglobulin, a molecule known for its capacity to inhibit the oxidation of low-density lipoprotein particles and thereby mitigate vascular damage. These multifaceted functions underscore the critical role of MPO in immune defense and vascular protection.

rHuMyeloperoxidase/MPO, His; Myeloperoxidase; MPO

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of 20 mM Citrate, 6% Trehalose, 4% Mannitol, 0.05% Tween 80, pH 5.0 or 50 mM Tris-HCL, 300 mM NaCl, pH 7.4 or 50 mM Tris-HCL, 300 mM NaCl, pH 7.4, 8% trehalose.

Room temperature in continental US; may vary elsewhere.