protein

sFRP-3 Protein, Mouse (HEK293, His)

HY-P702549

5 μg;10 μg;50 μg

185;300;840 USD

sFRP-3 Protein, Mouse (HEK293, His)

proteins

HEK293

5 μg;10 μg;50 μg

185;300;840 USD

The sFRP-3 protein is a soluble Frizzled-related protein that modulates Wnt signaling by directly interacting with Wnt, thereby regulating cell growth and differentiation. Known as FRZB, it acts as a Wnt8 signaling antagonist with crucial effects on limb skeletogenesis. sFRP-3 Protein, Mouse (HEK293, His) is the recombinant mouse-derived sFRP-3 protein, expressed by HEK293 , with C-6*His labeled tag.

Mouse

sFRP-3, a soluble frizzled-related protein, operates as a modulator of Wnt signaling through its direct interaction with Wnts, contributing to the regulation of cell growth and differentiation in specific cell types. Notably, SFRP-3, also known as FRZB, plays a key role in limb skeletogenesis, functioning as an antagonist of Wnt8 signaling. Its regulatory influence extends to chondrocyte maturation and long bone development. In addition to its participation in Wnt signaling modulation, SFRP-3 interacts with MYOC, showcasing its engagement in molecular interactions associated with cellular processes. These diverse functions underscore the multifaceted regulatory role of sFRP-3 in Wnt-mediated pathways and skeletogenesis.

FIZ; FREOS1; Frezzled; Fritz; Frizzled-related protein 1; frizzled-related protein; FRP; FRP-3; FRZB; Frzb1; FRZB-1; FRZB1sFRP-3; FRZB-PEN; FZRB; hFIZ; secreted frizzled-related protein 3; sFRP3; sFRP-3; SFRP3frezzled; SRFP3frizzled homolog-related

Greater than 95% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4, 8% trehalose.

Room temperature in continental US; may vary elsewhere.