protein

LRP-1 Cluster II Protein, Human (HEK293, His)

HY-P702520

2 μg;10 μg;50 μg;100 μg

30;75;215;340 USD

LRP-1 Cluster II Protein, Human (HEK293, His)

proteins

HEK293

2 μg;10 μg;50 μg;100 μg

30;75;215;340 USD

LRP-1 Cluster II protein is involved in endocytosis and phagocytosis of apoptotic cells. The LRP-1 Cluster II protein also serves as a receptor for Pseudomonas aeruginosa exotoxin A during microbial infection. LRP-1 Cluster II Protein, Human (HEK293, His) is the recombinant human-derived LRP-1 Cluster II protein, expressed by HEK293 , with C-10*His labeled tag. The total length of LRP-1 Cluster II Protein, Human (HEK293, His) is 380 a.a., .

Human

LRP-1 Cluster II Protein emerges as a multifunctional endocytic receptor, playing pivotal roles in both endocytosis and the phagocytosis of apoptotic cells. Its significance extends to essential functions in early embryonic development and cellular lipid homeostasis. Additionally, LRP-1 Cluster II is actively involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the localized metabolism of complexes formed between plasminogen activators and their endogenous inhibitors. Acting as an LRPAP1 alpha-2-macroglobulin receptor, it further participates in various cellular events, including the endocytosis and subsequent spread of TAU/MAPT. Moreover, LRP-1 Cluster II may modulate critical cellular processes such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling, and neurotransmission. Notably, in microbial infection, the protein functions as a receptor for Pseudomonas aeruginosa exotoxin A, highlighting its diverse and intricate roles in cellular physiology and host-pathogen interactions.

A2MR; Alpha-2-Macroglobulin Receptor; APOER; APR; CD91; LRP1 Cluster II; LRP-1 Cluster II; LRP1; TGFBR5

Greater than 90% as determined by reducing SDS-PAGE.

Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4, 8% trehalose.

Room temperature in continental US; may vary elsewhere.